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Publications

NTU

  1. Ferdinandus, Jie Ren Tan, Jin Heng Lim, Satoshi Aria, Keitaro Sou and Chi-Lik Ken Lee. (2022). Squaraine probes for bimodal staining of lipid droplets and endoplasmic reticulum imaging in live cell. Analyst, 147, 3570-3577. https://doi.org/10.1039/D2AN00803C [IF4.616].

  2. Jie Ren Tan, Ferdinandus, Bengang Xing and Chi-Lik Ken Lee. (2022). Functionalization of thermoswitchable liposomes for rapid detection of Gram-negative bacteria. Sens. Actuators, B. 367, 132123. https://doi.org/10.1016/j.snb.2022.132123 [IF 7.335].

  3. Natsumi Ichikawa, Li Shiuan Ng, Saneyuki Makino, Luo Lin Goh, Yun Jia Lim, Ferdinandus, Hiroyuki Sasaki, Shigenobu Shibata and Chi-Lik Ken Lee. (2022). Solid-State Fermented Okara with Aspergillus spp. Improves Lipid Metabolism and High-Fat Diet Induced Obesity. Metabolites. 12(3), 198. https://doi.org/10.3390/metabo12030198 [IF 4.754]  

  4. Cheng Pau Lee, Masaki Takahashi, Satoshi Arai, Chi-Lik Ken Lee and Michinao Hashimoto. (2021). 3D Printing of Okara Ink: The Effect of Particle Size on the Printability. ACS Food Sci & Tech. 1, 11, 2053-2061. https://doi.org/10.1021/acsfoodscitech.1c00236 [IF 1.718]

  5. Adwin Ong and Chi-Lik Ken Lee. (2021). Cooperative metabolism in mixed culture solid-state fermentation. LWT-Food Sci. Technol. 152, 12300. https://doi.org/10.1016/j.lwt.2021.112300.

  6. Winnie Faustinelie and Chi-Lik Ken Lee. (2021). Nutritional Analysis of Biovalorisaton of Homogeneous Food Processing By-products. ChemRxiv. Cambridge: Cambridge Open Engage. https://doi.org/10.26434/chemrxiv.14540178.v1

  7. Luo Lin Goh and Chi-Lik Ken Lee. (2021). Biovalorisation of Brewer’s spent grain (BSG) and sensory evaluation of BSG bread. ChemRxiv. Cambridge: Cambridge Open Engage. https://doi.org/10.26434/chemrxiv.14491842.v1

  8. Jin Heng Lim and Chi-Lik Ken Lee. (2021). Thermosensitive fluorescent liposomes. ChemRxiv. Cambridge: Cambridge Open Engage. https://doi.org/10.26434/chemrxiv.14483067.v1

  9. Jia Shen Chew, Thi Thanh Nha Ho and Chi-Lik Ken Lee. (2021). Biocatalytic ketone reductions using Biobeads for miniaturized high throughput experimentation. New J. Chem., 45, 32-35. https://doi.org/10.1039/D0NJ04889E

  10. Keitaro Sou, Li Yan Chan, Satoshi Arai and Chi-Lik Ken Lee. (2019). Highly cooperative fluorescence switching of self-assembled squaraine dye at tunable threshold temperatures using thermosensitive nanovesicles for optical sensing and imaging. Sci. Rep. 9, 17991. doi:10.1038/s41598-019-54418-1.

  11. Joel Chia, Yu Pei Tay, Daniel Poh, Boon Hunt Tay, Eileen Koh, Joshua Teo, Hoi Ming Yap, Merrill Lim, Li Ting Soh, Yuan Kun Lee and Chi-Lik Ken Lee. (2019). Development and evaluation of a rapid on-site water pathogen detection system for water quality monitoring. BioRxiv. doi:10.1101/731778.

  12. Li Yan Chan, Masaki Takahashi, Pei Jean Lim, Shinya Aoyama, Saneyuki Makino, Ferdinandus, Ferdinandus, Shi Ya Clara Ng, Satoshi Arai, Hideaki Fujita, Hong Chang Tan, Shigenobu Shibata and Chi-Lik Ken Lee.(2019). Eurotium Cristatum fermented Okara as a potential food ingredient to combat diabetes. Sci. Rep. 9, 17536. doi:10.1038/s41598-019-54021-4.

Before NTU

  1. Li Yan Chan, Joshua Ding Wei Teo, Kevin Shyong-Wei Tan, Keitaro Sou, Wei Lek Kwan and Chi-Lik Ken Lee. (2018). Near Infrared Fluorophore-Tagged Chloroquine in Plasmodium falciparum Diagnostic Imaging. Molecules. 23, 2635-2648. doi:10.3390/molecules23102635.

  2. Sheng Dong, Joshua Ding Wei Teo, Li Yan Chan, Chi-Lik Ken Lee and Keitaro Sou. (2018). Far-red Fluorescent Liposomes for Folate Receptor-targeted Bioimaging. ACS Appl. Nano Mater. 1 (3), 1009-1013. doi:10.1021/acsanm.8b00084.

  1. Keitaro Sou, Li Yan Chan and Chi-Lik Ken Lee. (2016). Fluorescence on/off switching on self-assembled rhodamine B derivative by sensing pH and UV light. Journal of Photochem. and Photobio. A: Chemistry. 332, 25-31.doi:10.1016/j.photochem.2016.08.001.

  2. Keitaro Sou, Li Yan Chan and Chi-Lik Ken Lee. (2016). Temperature tracking in a three-dimensional matrix using thermosensitive liposome platform. ACS Sensors, 6, 650-655. doi:10.1021/acssensors.6b00222.

  3. Satoshi Arai, Chi-Lik Ken Lee, Young-Tae Chang, Hirotaka Sato and Keitaro Sou. (2015). Thermosensitive nanoplatforms for photothermal release of cargo from liposomes under intracellular temperature monitoring. RSC Advances, 5, 93530-93538. doi:10.1039/c5ra10729e.

  4. Xiaoqian Liu, Bokun Cho, Li-Yan Chan, Wei Lek Kwan and Chi-Lik Ken Lee. (2015). Development of asymmetrical near infrared squaraines with large Stokes shift. RSC Advances, 5, 106868-106876. doi:10.1039/c5ra18998e.

  5. Liyun Zhang, Jun Cheng Er, Xin Li, Jun Jie Heng, Animesh Samanta, Young-Tae Chang and Chi-Lik Ken Lee (2015).Development of Fluorescent Probes Specific for Parallel-Stranded G-Quadruplexes by Library Approach. Chem. Comm., 51, 7386-7389. doi:10.1039/c5cc01601k.

  6. Wang Xu, Changliang Ren, Chai Lean Teoh, Juanjuan Peng, Shubhankar Haribhau Gadre, Hyun-Woo Rhee, Chi-Lik Ken Lee and Young-Tae Chang. (2014). An Artificial Tongue Fluorescent Sensor Array for Identification and Quantitation of Various Heavy Metal Ions. Anal. Chem., 86, 8763-8769. doi:10.1021/ac501953z.

  7. Liyun Zhang, Jun Cheng Er, X Qin, Animesh Samanta, S Jana, Chi-Lik Ken Lee and Young-Tae Chang. (2014). "Orange Alert": A Fluorescent Detector for Bisphenol A in Water Environments. Anal. Chim. Acta, 815, 51-56. doi:10.1016/j.aca.2014.01.038.

  8. Li-Min Tan, Zhi-Yu Sem, Wei-Yuan Chong, Xiaoqian Liu, Hendra, Wei Lek Kwan and Chi-Lik Ken Lee. (2013). Continuous Flow Sonogashira C-C Coupling Using a Heterogeneous Palladium-Copper Dual Reactor. Org. Lett., 15, 65-67. doi:10.1021/ol303046e.

  9. Chi-Lik Ken Lee, Zhi-Yu Sem, Hendra, Xiaoqian Liu and Wei Lek Kwan. (2013). Enhancement of Nucleophilic Aromatic Substitutions by the Synergistic Effects of Microcavitation and Continuous Flow Chemistry. J. Flow. Chem., 3, 114-117. doi:10.1556/jfc-d-13-00015.

  10. Swee Ling Lam, Xiaoqian Liu, Fangli Zhao, Chi-Lik Ken Lee and Wei Lek Kwan. (2013). Manipulating Open-Circuit Voltage in Organic Photovoltaic Device via a Phenylalkyl Side Chain. Chem. Comm., 49(40), 4543-4545. doi:10.1039/c3cc40403j.

  11. Marc Vendrell, Sung-Jin Park, Yogeswari Chandran, Chi-Lik Ken Lee, Hyung-Ho Ha, Nam-Young Kang, Seong-Wook Yun and Young-Tae Chang. (2012). A Fluorescent screening platform for the rapid evaluation of chemicals in cellular reprogramming. Stem Cell Res., 9, 185-191. doi:10.1016/j.scr.2012.06.006.

  12. Rui Jie Peh, Yanru Lu, Fangli Zhao, Chi-Lik Ken Lee and Wei Lek Kwan. (2011). Vacuum-free Processed Transparent Inverted Organic Solar Cells with Spray-coated PEDOT:PSS Anode. Solar Energy Material & Solar Cells, 95, 3579-3584. doi:10.1016/j.solmat.2011.09.018.

  13. Haishan Wang, Niefang Yu, Dizhong Chen, Chi-Lik Ken Lee, Pek Ling Lye, Joyce Wie Wie Chang, Weiping Deng, Melvin Chi Yeh Ng, Ting Lu, Mui Ling Khoo, Anders Poulsen, Kanda Sangthongpitag, Xiaofeng Wu, Changyong Hu, Kee Chuan Goh, Xukun Wang, Lijuan Fang, Kay Lin Goh, Hwee Hoon Khng, Siok Kun Goh, Pauline Yeo, Xin Liu, Zahid Bonday, Jeanette M. Wood, Brian W. Dymock, Kantharaj Ethirajulu and Eric T. Sun. (2011). Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1Hbenzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile. J. Med. Chem., 54, 4694-4720. doi:10.1021/jm2003552.

  14. Haishan Wang, Ze-Yi Lim, Yan Zhou, Melvin Chi Yeh Ng, Ting Lu, Chi-Lik Ken Lee, Kanda Sangthongpitag, Kee Chuan Goh, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Wai Chung Ong, Zahid Bonday and Eric T. Sun. (2010). Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg. & Med. Chem. Lett., 20, 3314-3321. doi:10.1016/j.bmcl.2010.04.041

  15. Chi-Lik Ken Lee and Teck-Peng Loh. (2005). Gram-Scale Synthesis of (-)-Epibatidine. Org. Lett., 7, 2965-2967.doi:10.1021/ol0508911.

  16. Chi-Lik Ken Lee, Hui Yvonne Ling and Teck-Peng Loh. (2004). Asymmetric Synthesis of C-Aliphatic Homoallylic Amines and Biologically Important Cyclohexenylamine Analogues. J. Org. Chem., 69, 7787-7789. doi:10.1021/jo048903o.

  17. Chi-Lik Ken Lee, Cheng-Hsia Angeline Lee, Kui-Thong Tan and Teck-Peng Loh. (2004). An Unusual Approach to the Synthesis of Enantiomerically Cis Linear Homoallylic Alcohols Based on the Steric Interaction Mechanism of Camphor Scaffold. Org. Lett., 6, 1281-1283. doi:10.1021/ol049633z.

  18. Chi-Lik Ken Lee, Kui-Thong Tan and Teck-Peng Loh. (2002). The First Example of Enantioselective Allyl Transfer from a Linear Homoallylic Alcohol to an Aldehyde. Org. Lett., 17, 2985-2987. doi:10.1021/ol0263999.

Patents

  1. Chi-Lik Ken Lee and Joel Y. Chia. (2017). System and Method for On-Site Detection of Pathogens. SG Patent Appl. (10201801064R).

  2. Chi-Lik Ken Lee, Wei Lek Kuan, Ashley Chen and Kian Hwa Tan. (2014). Method for RNA Virus Detection. SG Patent Appl. (10201400214T). 

  3. Chi-Lik Ken Lee and Young-Tae Chang. (2013). Small Molecule Fluorescent Sensors to Quantitatively Identify Heavy Metal Ions. US Provisional Patent Appl. (62/011,870). 

  4. Chi-Lik Ken Lee and Mun Kin Leong. (2011). System and Method for Providing Mixed Mode Energies During A Continuous Chemical Flow Process. SG Patent Appl. (201107544-7).

  5. Chi-Lik Ken Lee, Yew Boon Soon, Mun Kin Leong, Tze An Ryan Lam and Sze Wei Sharon Gan. (2011). Handheld Solid Dispenser. PCT Int. Appl. WO2012044253.

  6. Chi-Lik Ken Lee, Eric T Sun and Haishan Wang. (2008). Preparation of imdazo[1,2-a]pyridine hydroxamate compounds as inhibitors of histone deacetylase. PCT Int. Appl. 92pp. WO 2008036046.

  7. Dizhong Chen, Weiping Deng, Chi-Lik Ken Lee, Pek Ling Lye, Eric T. Sun, Haishan Wang and Niefang Yu. (2007). Heterocyclic compounds as HDAC inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases associated with enzymes that have HDAC activity. PCT Int. Appl. 185pp. WO 2007030080.

  8. Chi-Lik Ken Lee and Eric T Sun. (2006). Imidazo[1,2-a]pyridine derivatives as histone deacetylase inhibitors and their preparation and pharmaceutical applications. PCT Int. Appl. 148pp. WO 2006101455.

Publications : Publications
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